Kitchen supplies for catering business ~ Teczcape-An Escape to Food

Have you ever used the coffee maker in your hotel room? Then, have you ever wondered how did this coffee maker made its way to the room? During extended road trips, returning to a hotel/motel room that comes with a basic kitchen can make the guests feel at home.
If you are operating a motel or bed and breakfast business, you might be interested to check out PeachSuite.com which is not only a Hotel Supply site but also caters to resort supplies and equipment. In fact if you are in hospitality business, this site has lots to offer.

Have you dream of making catering your business? Think big and be much more creative. You can set up a carving station in a catering-style buffet for your customers. Start with a carving station and end with a chocolate fondue fountain - to impress. And PeachSuite.com is there to help you in all the quality supplies and service you need. As it caters for hotel, resort, catering or restaurant business, FREE SHIPPING is only offered to qualifying retail purchases over $500.? Hotel Bar Supplies offered by PeachSuite.com is extensive as well - from the bar equipment, bartender supplies, server supplies and even game supplies. In additional, you can also find Georgia Hotel Supplies Online .

Source: http://teczcape.blogspot.com/2013/02/kitchen-supplies-for-catering-business.html

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Cops hunt 7 kids in 'possible family abduction' case

Fresno Police Department

Five of the seven children missing from Fresno, Calif.

By John Newland, Staff Writer, NBC News

Police are searching for seven children who vanished from their Fresno, Calif., home Saturday.

Investigators are treating it as a "possible family abduction" case.

Ranging in age from 5 to 12, the kids were left at home while their mother and stepfather went to a grocery store, according to the Fresno Police Department.?

Police believe that their biological father "picked up all of the children." He was?identified as Xa Yang and is thought to live in Sacramento, about 170 miles north of Fresno.

Neither authorities nor the children's mother had been able to contact the father, who had not been involved in the children's lives "for at least three years," according to a police statement.?

Because the seven children, along with their belongings, were removed from an apartment complex in the early evening without any apparent commotion, investigators do not suspect foul play.

There was no immediate concern for the children's safety, police said.

While they have not issued an "Amber Alert," which are normally issued in suspected abductions, police are seeking the public's help.

Anyone with information can call Detective Josh Mendizabal at (559) 621-2499 or (559) 621-7000.

Source: http://usnews.nbcnews.com/_news/2013/02/28/17129230-cops-hunt-7-missing-children-in-possible-family-abduction-case?lite

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Deaths of teen drivers jumped in early 2012

WASHINGTON (AP) ? Deaths of younger teen drivers increased sharply in the first six months of last year, reversing a decade-long trend, according to a report released Tuesday by state highway safety officials.

Deaths of 16- and 17-year-old drivers in traffic accidents in the first six months of 2012 were up a combined 19 percent over the same period in the previous year, according to the report from the Governors Highway Safety Association.

There were 107 drivers aged 16 who died between January and June of last year, compared to 86 drivers during the first half of 2011.

Deaths of 17-year-old drivers rose from 116 in the first half of 2011 to 133 in the first half of last year.

The report is based on preliminary state data that sometimes changes. The National Highway Traffic Safety Administration is expected to release more definitive data later this year.

Twenty-five states reported increases, 17 had decreases, and eight states and the District of Columbia reported no change in the number of 16- and 17-year-old driver deaths.

"Despite our efforts, teens remain our most vulnerable population," said Kendall Poole, head of the Tennessee highway safety office and chairman of the safety association. "With the advances in technology, we suspect distracted driving deaths among teen drivers are rising."

Jacqueline Gillan, president of Advocates for Highway and Auto Safety, said the increase in deaths of teen drivers "should motivate governors and legislative leaders to make passage of stronger teen driving laws an urgent priority."

Deaths of novice drivers dropped dramatically over the past decade at a time when many states were imposing greater restrictions on teen drivers, including limits on driving with teen passengers or driving at night.

There were 435 16-year-old drivers killed in all of 2000. That total dropped to 173 by 2011.

A similar trend occurred with 17-year-old drivers as the number of deaths dropped from 564 to 250 during the same time frame.

"We are still at a much better place than we were 10 or even five years earlier," said researcher Allan Williams, the report's author and former chief scientist at the Insurance Institute for Highway Safety. "However, the goal is to strive toward zero deaths, so our aim would be that these deaths should go down every year."

It's difficult to know exactly why teen driving deaths declined so dramatically, or why they now appear to be on an upswing, researchers said.

The long-term decline in teen driver deaths coincided with a historic, although more gradual, decline in traffic fatalities overall. That decline also appears to have been arrested. A report last week by National Safety Council said traffic fatalities rose 5 percent last year. It's the first increase since 2004 to 2005.

___

Follow Joan Lowy on Twitter at http://www.twitter.com/AP_Joan_Lowy

___

Online:

Governors Highway Safety Association http://www.ghsa.org

Source: http://news.yahoo.com/deaths-teen-drivers-jumped-early-2012-050611775.html

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Ohio court hearing arguments in school Bible case

COLUMBUS, Ohio (AP) ? Attorneys for a fired public school science teacher who kept a Bible on his desk plan to argue before the Ohio Supreme Court that the teacher's dismissal was unconstitutional.

The Mount Vernon School Board dismissed John Freshwater in 2011 after investigators reported he preached Christian beliefs in class when discussing topics such as evolution and homosexuality and was insubordinate in failing to remove the Bible from his classroom.

Freshwater also was accused of using a science tool to burn students' arms with the image of a cross, but that allegation was resolved and was not a factor in his firing.

Two lower courts previously upheld Freshwater's dismissal, but the state Supreme Court agreed to hear a portion of his claims over his firing. The hearing was to be held Wednesday.

The court said Freshwater can argue it is unconstitutional to fire someone without clear guidance on what teaching materials or methods are acceptable. Freshwater also can argue it is unconstitutional to fire someone over the mere presence of a religious text such as the Bible in a classroom.

As an eighth-grade science teacher, Freshwater tried to encourage his students to examine facts and theories and hypotheses and then question them and differentiate between them, his attorney said in a court filing last year.

A voluntary discussion of creationism or "intelligent design" as part of the mandatory discussion of evolution is unquestionably part of a secular education program, attorney Kelly Hamilton wrote.

"Freshwater did not engage in religious proselytization ? he discussed a scientific theory that happens to be consistent with the teachings of multiple major world religions," Hamilton wrote.

The board's actions, he concluded, were nothing less "than the censorship of ideas."

Freshwater is getting legal backing from the Charlottesville, Va.-based Rutherford Institute, a civil liberties group.

Attorneys for the school board countered that Freshwater had long tried to push religion in the classroom.

As far back as 1994, a middle school principal told Freshwater to stop distributing an "Answers in Genesis" pamphlet with information about a creationist organization's upcoming seminar, according to a filing by board attorneys asking the court to uphold Freshwater's firing.

Freshwater also used a handout titled "Survival of the Fakest," to teach his students to doubt science, the board's attorneys said.

"Whenever Freshwater was told by a superior to cease using an inappropriate handout in class, he would simply find another one to use," the board's attorneys said in a filing last fall.

Science education and humanist and secular groups have joined the side of the school board.

The board once concluded Freshwater had used a high-frequency generator, which other teachers have used to demonstrate electrical current, to burn a cross onto a student's arm. The cross lasted a few weeks.

The student's family settled a federal lawsuit against the district in an effort to move on.

___

Andrew Welsh-Huggins can be reached at http://twitter.com/awhcolumbus

Source: http://news.yahoo.com/ohio-court-hearing-arguments-school-bible-case-073731719.html

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Pets Deserve Food Stamps Just As Much As the Rest of the Family ...

Hey, ready to disagree with somebody on something? Here's an idea that some people are bound to love and others are bound to hate: Food stamps ... for pets.?Considering the (unfair) criticism human beings on food stamps get, I'm guessing the very thought of such assistance for animals won't go over well with certain people. (Those damn freeloading pets! Get a job, Whiskers!) But personally, I think it's a fabulous idea, one that has the potential to literally change lives for the better -- human, canine, feline, and so on.

And even the most conservative, anti-hand-out types won't be able to complain when they find out where the money is coming from. (Hint: NOT the government.)

Based in New York, the Pet Food Stamps program is donation-based and open to anyone in the United States who meets need and income qualifications. Once accepted, enrollees receive pet food each month from Pet Food Direct for six months; in the past 2 weeks, over 45,000 pets have signed up.

What a relief this must be for those families! Times are tough and for so many, it's hard enough just keeping the humans sitting at the table fed, let alone the hungry dog waiting underneath the table, hoping somebody slips him some chicken on the sly. But the thought of abandoning or even giving away a beloved pet because you can't afford to buy food is just heartbreaking.

Look, I get it if some people are rolling their eyes right now. I wasn't allowed to have animals (not counting goldfish, which I don't) growing up, so it wasn't until the fairly recent arrival of our Pit Bull/Eskimo mix that I truly developed an understanding of what it means to be a pet owner. And honestly, I was surprised to discover that in some ways, it's not all that different from being a parent. Maybe that should've been obvious -- everybody knows puppies poop all over the place and whimper and chew on everything and need shots and stuff -- but, as with parenting, I just wasn't prepared for how much I would love this little thing. (I especially wasn't prepared for how much she would love me!) Maybe, before I had this experience for myself, I wouldn't have understood the need for Pet Food Stamps either.

But there IS a need!

What do you think about the idea of food stamps for pets?

?

Image via Timothy Joel Wright/Flickr

Source: http://thestir.cafemom.com/home_garden/151735/pets_deserve_food_stamps_just

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They Do?! The Most Surprising Celebrity Weddings

Forget something borrowed, something blue -- these weddings were out of the blue! From Janet Jackson & Wissam Al Mana to Blake Lively & Ryan Reynolds, check out the star nuptials that shocked us.

Source: http://www.ivillage.com/surprising-celebrity-weddings/1-b-360908?dst=iv%3AiVillage%3Asurprising-celebrity-weddings-360908

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Survey Anecdote Suggests We Have No Idea What?s Going On At Google+

By Google's count, Google+ has over 500 million "upgraded" members and some 135 million people active "in just the stream." By researchers' best estimates, however, the answer is a bit more complicated.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/9EkEcL8o-fw/

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AT&T snags OnStar wireless contract from Verizon

BARCELONA, Spain (AP) ? AT&T Inc. is scoring a win over rival Verizon Wireless as it takes over the contract to supply wireless connections to cars with General Motors' OnStar service.

Verizon Wireless and its predecessor companies have supplied the network for OnStar since the service launched in the 1990s, but AT&T will take over with the 2015 model year, AT&T and GM said Monday.

The news comes as cellphone companies are jostling to connect non-phone devices to their networks. Now that nearly everyone has a phone, the phone companies have to look elsewhere for growth. Dallas-based AT&T has been particularly aggressive in this area, garnering, for instance, the contract to connect Amazon Kindle e-readers.

AT&T will connect OnStar cars to its new "4G LTE" network, which can supply much higher data speeds than current OnStar connections. That means GM could deliver car software updates wirelessly, instead of making owners take their cars to the shop. It could also enable video streaming for passengers, in-vehicle Wi-Fi "hotspots" and give GM a better view of what's going on inside a car, and whether it needs maintenance. Owners might even be able to call up views from their car's cameras, remotely.

"They're basically smartphones on wheels," said Glenn Lurie, head of AT&T's "emerging devices" division.

Verizon has an LTE network that delivers speeds similar to AT&T's, with wider coverage. Lurie said that by the time AT&T takes over the contract, its LTE network will cover 300 million Americans, or 96 percent of the population. It also has older, slower networks as a backup.

Verizon Wireless said it was looking forward to continuing to provide service to current OnStar customers.

AT&T and GM made the announcement just before the opening of Mobile World Congress, the world's largest wireless trade show, in Barcelona. The companies didn't reveal financial terms. The 6 million current OnStar users pay $19 per month or $199 per year, plus per-minute calling fees. Turn-by-turn GPS navigation costs extra, too.

British automotive research firm SBD believes that 100 million cars worldwide will have built-in wireless capabilities by 2015.

___

AP Auto Writer Tom Krisher contributed from Detroit.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-02-25-EU-TEC-Wireless-Show-GM-OnStar-ATandT/id-07661a066a7545e580c5df55c61c4b57

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Ronda Rousey was more worried about her sports bra staying on than being submitted

During their main event bout at UFC 157, Liz Carmouche took Ronda Rousey's back and had her in a neck crank. The crank was so deep that Rousey inadvertently bit Carmouche's arm. But Rousey told the Fuel TV aftershow that she was never worried about submitting to Carmouche. Instead, she was concerned about a wardrobe malfunction.

?On the ground I feel so comfortable in every position, so I never feel in danger and I take a lot of risks. I felt fine with her on my back. I was more concerned with my sports bra staying on while she was choking me because I felt safe and in control," Rousey said.

Rousey won a bronze medal in the 2008 Olympics in judo, so submissions have been part of her life for a long time. In fact, Rousey has spoken often about how her mother taught her judo by waking her up with an armbar. While the neck crank was uncomfortable, it wasn't new.

What is new is having to worry about a sports bra not doing its job. Come on, sports bra. You had one job. Thankfully, it did stay in place, and Rousey went on to submit Carmouche seconds before the end of the first round.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ronda-rousey-more-worried-her-sports-bra-staying-204248185--mma.html

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Clues to climate cycles dug from South Pole snow pit

Feb. 25, 2013 ? Particles from the upper atmosphere trapped in a deep pile of Antarctic snow hold clear chemical traces of global meteorological events, a team from the University of California, San Diego and a colleague from France have found.

Anomalies in oxygen found in sulfate particles coincide with several episodes of the world-wide disruption of weather known as El Ni?o and can be distinguished from similar signals left by the eruption of huge volcanoes, the team reports in the early online edition of the Proceedings of the National Academy of Sciences published the week of February 25.

"Our ability to link of reliable chemical signatures to well-known events will make it possible to reconstruct similar short-term fluctuations in atmospheric conditions from the paleohistory preserved in polar ice," said Mark Thiemens, Dean of the Division of Physical Sciences and professor of chemistry and biochemistry, who directed the research and dug up much of the snow.

Thiemens, graduate student Justin McCabe and colleague Joel Savarino of Laboratoire de Glaciologie et G?ophysique de l'Environnment in Grenoble, France, excavated a pit 6 meters deep in the snow near the South Pole, with shovels.

"At an elevation of 10,000 feet and 55 degrees below zero, this was quite a task," Thiemens said. Their efforts exposed a 22 year record of snowfall, a pileup of individual flakes, some of which crystallized around particles of sulfate that formed in the tropics.

Atmospheric sulfates form when sulfur dioxide -- one sulfur and two oxygen molecules -- mixes with air and gains two more oxygen molecules. This can happen a number of different ways, some of which favor the addition of variant forms of oxygen, or isotopes, with and extra neutron or two, previous work by Thiemens's group has shown.

Unlike polar ice, which compresses months of precipitation so tightly that resolution is measured in years, relatively fluffy snow allowed the team to resolve this record of atmospheric chemistry on a much finer scale.

"That was key," said Robina Shaheen, a project scientist in Thiemen's research group who led the chemical analysis. "This record was every six months. That high resolution made it clear we can trace a seasonal event such as ENSO."

ENSO, the El Ni?o Southern Oscillation, is a complex global phenomenon that begins when trade winds falter allowing piled up in the tropical western Pacific to slosh toward South America in a warm stream that alters marine life crashing fisheries off Peru and Chile, and disrupts patterns of rainfall leaving parts of the planet drenched and others parched.

The warmed air above the sea surface lifts sulfur dioxide high into the stratosphere, where it's oxidized by ozone, which imparts a distinctly different, anomalous pattern of oxygen variants to the resulting sulfate particles.

In the Antarctic snow samples, the chemists found traces of these oxygen anomalies in sulfates trapped within layers of snow that fell during strong El Ni?o seasons.

Volcanoes too can shoot sulfur compounds high into the atmosphere where they react with ozone to produce sulfates with oxygen anomalies. Three large volcanoes, El Chich?n, Pinatubo and Cerro Hudson, erupted over the course of this time sample, which stretched from 1980 to 2002 and encompassed three ENSO events as well.

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Story Source:

The above story is reprinted from materials provided by University of California - San Diego.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. S. Chakraborty, T. L. Jackson, M. Ahmed, M. H. Thiemens. Sulfur isotopic fractionation in vacuum UV photodissociation of hydrogen sulfide and its potential relevance to meteorite analysis. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1213150110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/LfVdYx0ik8Q/130225153126.htm

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Doctors take Harper government to court over refugee health-care cuts

By?Obert Madondo?|?The Canadian Progressive, Feb. 25, 2013:

Jason Kenney, Canada?s Immigration Minister

Canadian refugee lawyers, advocacy groups, doctors and patients are banding together to file a lawsuit ?against the Harper government?s recent draconian cuts to health care for refugees. The group from the?Canadian Association of Refugee Lawyers (CARL), ?Canadian Doctors for Refugee Care (CDRC), and three individual patients, says the?cuts violate the fundamental rights of refugees as protected by the Canadian Charter of Rights and Freedoms.

The group is asking the Federal Court of Canada to declare the cuts unconstitutional and illegal.

?The cuts violate the fundamental human rights of refugees,? the group said in a statement issued Friday.??They cause unwarranted sufferings to countless individuals, and unnecessary costs to the Canadian health care system.?

The cuts were implemented through the Conservatives? Bill C-31, the so-called ?Protecting Canada?s Immigration System Act?, which passed in Parliament last June and came into effect on December 15, 2012.

The Canadian Medical Association Journal has warned that the cuts?pose?serious mental health risks for refugees. Daniel Garcia Rodriguez, a refugee applicant,?almost went blind?as a result of the cuts.?Other experts have argued that the bill will not give refugees a fair chance to tell their stories.

After the bill passed, Jewish-American political activist, Nobel laureate, writer, professor, Elie Wiesel, joined tens of thousands of Canadians who vocally condemned the cuts.

?I feel morally compelled to remain on the side of other uprooted men and women everywhere.?Today, as yesterday, a nation is judged by its attitude towards refugees,? said the?Holocaust survivor.

The majority of the refugees severely impacted are persons of color and trauma survivors, two facts Conservatives seem to be unmoved by.

Just after the bill passed, its architect and Minister of Citizenship and Immigration, Jason Kenney, posted a petition on his personal website?asking Canadians to thank him for a job well done.

?We, the undersigned, thank Jason Kenney for his efforts to streamline benefits afforded to refugees claimants under the Interim Federal Health Program (IFHP) and bring them in line with the benefits received by tax-paying Canadians, including new Canadians,? the petition said.

The House of Commons? Standing Committee on Public Safety and National Security?recently?recommended?the?use of electronic ankle bracelets?on failed refugee claimants to keep a tab on their movements. The committee is?chaired by?Conservative MP Kevin Sorenson.

Last October, Kelly Block, the Conservative MP for Saskatoon-Rosetown-Biggar, ?celebrated? Jason?s cuts with a?flyer?mailed to members of her riding.

?New arrivals to Canada have received dental and?vision care paid by your tax dollars. They?ve had free prescriptions. Not anymore,? the flyer read.

In the House of Commons, Official Opposition NDP called on Block to apologize. ?She is bragging about denying medication for kidney disease to an elderly woman or?care to a young woman who is 18 weeks pregnant due to a sexual assault,? ?said Jinny?Sims, the NDP MP for Newton-North Delta in B.C. ?This flyer is offensive and misleading.?Will the member apologize??

The Canadian Progressive recommends:

Obert Madondo is the founder and publisher of The Canadian Progressive. He?s a fearless and passionate activist, progressive political blogger, writer, journalist, public speaker and publisher. He?s worked as speechwriter to Margaret Dongo, a former Independent Zimbabwean MP. He's worked as a senior international development executive with the Konrad Adenauer Foundation, a Germany international development agency, and with a Canadian charity. Obert is published or quoted here: The Huffington Post, CBC News, Ottawa Citizen, The Canadian Progressive, Toronto Sun, Rabble.ca, Metro News, The Charlatan, EMC Kanata, The Dominion, Ground Report, AfricaFiles & New Zimbabwe

Share the post "Lawyers, doctors take Harper government to court over refugee health-care cuts"

Source: http://www.canadianprogressiveworld.com/2013/02/25/doctors-lawyers-legally-challenge-harpers-refugee-health-care-cuts/

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94% Zero Dark Thirty

All Critics (234) | Top Critics (44) | Fresh (219) | Rotten (15)

What's striking is the absence of triumphalism -- Bigelow doesn't shy away from showing the victims shot down in cold blood in the compound -- and we come away with the overwhelming sense that this has been a grim, dark episode in our history.

Chastain makes Maya as vivid as a bloodshot eye. Her porcelain skin, delicate features and feminine attire belie the steel within.

No doubt Zero Dark Thirty serves a function by airing America's dirty laundry about detainee and torture programs, but in its wake, there's a crying need for a compassionate Coming Home to counter its brutal Deer Hunter.

While "Zero Dark Thirty" may offer political and moral arguing points aplenty, as well as vicarious thrills,as a film it's simply too much of a passable thing.

From the very first scenes of Zero Dark Thirty, director Kathryn Bigelow demonstrates why she is such a formidable filmmaker, as adept with human emotion as with visceral, pulse-quickening action.

A timely and important reminder of the agonizing human price of zealotry.

An exhilarating and compelling historical document worthy of praise.

Bigelow's latest proves a rewarding piece of filmmaking, one that, in its best moments at least, is as gripping and as troubling as anything the director's ever made.

Bigelow and screenwriter Mark Boal shape history -- those breaks, big and small, that led to the killing of Osama bin Laden -- into one of the finest fact-based thrillers since "All the President's Men."

Purely as cinematic exercise, Zero Dark Thirty is an exhilarating piece of work. But, beyond its for-the-times subject matter, the work does not linger whatsoever.

Zero Dark Thirty is interesting as opposed to enjoyable, intriguing as opposed to entertaining, and certainly less memorable than The Hurt Locker.

It's quite remarkable how Bigelow and Boal managed to take 12 years of information (including a conclusion that everyone knows) and packaged it into a coherent, intimate and intense movie.

We know the ending, yet remain mesmerized by familiar details, filmed with a harrowing sense of urgency. It's as close to being in the White House situation room that night, watching a closed-circuit broadcast, as anyone could expect.

The second half of the film IS the film.

Whereas Locker was less about war than what it is to have a death wish, ZDT is less about the suspenseful true-life search for Osama bin Laden than the red tape one woman must wade through to prove that a mean old bastard is living in suburban Pakistan.

Bigelow's great achievement is stripping down the action from the exaggerated theatrics in movies and television shows so the missions feel no less exciting and immediate.

One of the finest movies of the year is a thriller about the tracking and, finally, slaying of Osama bin Laden.

There is no Team America-style, flag-waving bravado behind this story - it is quite the opposite.

Bigelow has created the best film of 2012.

"Zero Dark Thirty" is less a celebration how terrorist mastermind Osama bin Laden was found and killed than an engrossing examination of why it took a decade to deal with him.

Following on from the great acclaim of The Hurt Locker, Bigalow's shaky cam and tough talking characters once again take us to the dark side of modern warfare.

In the absence of cinematic grandeur and didacticism, we're left as empty and as lost as Chastain's agent as she boards a symbolically empty plane for an uncertain future. Just what are we to think of the so-called War on Terror?

The viewer needs to stay sharp to stay on top of the details of the labyrinthine search, but Bigelow tackles the complex story with the same muscular urgency and incisive intelligence that won her an Oscar for The Hurt Locker.

Source: http://www.rottentomatoes.com/m/zero_dark_thirty/

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General mechanism that accelerates tumor development discovered

Feb. 24, 2013 ? Cancer is characterized by uncontrolled cell division and growth. In order to identify new therapeutic targets through which to tackle the disease, scientists seek to clarify the mechanisms that control the expression of genes that favor the development of tumors, in processes such as uncontrolled cell division. Nature has just published a paper by the lab headed by Ra?l M?ndez, ICREA professor at the Institute for Research in Biomedicine (IRB Barcelona). The study describes a mechanism controlled by the CPEB1 protein that affects more than 200 genes related to cell proliferation and tumor progression. The mechanism, which was discovered using Hodgkin lymphoma cells, has been proposed as a general regulatory system that enhances the spread of cancer.

The researchers describe that CPEB1 shortens a highly specific region of RNAs (RNAs are the molecules that carry gene information for protein synthesis). This region holds most of the signals that determine whether an RNA molecule is made into a protein or not. "CPEB1 "takes off the brakes" for hundreds of RNAs that stimulate cell desdifferentiation and proliferation, allowing them to be made into proteins; however, in addition to removing the brakes in the nucleus, this protein accompanies RNA to the cytoplasm, where it speeds up the production of these proteins," explains the senior author of the paper Ra?l M?ndez, head of the "Translational control of cell cycle and differentiation" group at IRB Barcelona.

Ra?l M?ndez is an expert on the CPBE protein family, a type of RNA-binding protein that has a positive and crucial role in early embryo development. "CPEB proteins are necessary during development and also during tissue regeneration via stem cells in adults, but if the programme governed by CPEBs is continually switched on, cells divide when they are not supposed to and form a tumor," explains M?ndez. The CPEB family comprises four proteins, which compensate each other's normal function but which have specific activities in diseased states. "This finding is positive from a therapeutic viewpoint because it means that if you remove CPEB1 from healthy cells, its function can be taken over by any other CPEB protein. In contrast, in tumors only CPEB1 has the capacity to shorten these regions, thus affecting only tumor cells," states Italian researcher Felice Alessio Bava, first author of the paper, and post-doctoral fellow with M?ndez's group who, this year, has obtained his doctorate degree through the "la Caixa" International Fellowship Programme. This study provides further evidence of the potential of CPEB proteins as therapeutic targets. In 2011, in a study published in Nature Medicine, M?ndez identified that CPEB4 "switches on" hundreds of genes linked to tumor growth. This new study explains that the overexpression of CPEB4 in tumors is because CPEB1 has also "released its brakes." "The fact that these proteins control each other is also advantageous from a therapeutic point of view," asserts M?ndez, "because partial inhibition, by a drug, would be amplified, thus allowing tumor cell reprogramming. The amplification should make it easier to find a viable compound."

The lab has developed a system to screen therapeutic molecules for a drug that can inhibit the action of CPEB in tumors while having few secondary effects on healthy cells. "There is no drug currently available that influences the regulation of gene expression at this level. Our findings open up a pioneering therapeutic window. We are optimistic about the potential of CPEB proteins as targets," says M?ndez.

The action of CPEB proteins should be considered in the design of other therapeutic strategies

The study published in Nature includes a meticulous genomic analysis of RNA molecules that are processed in different ways depending on whether CPBE1 is present. The study provides a list of between 200 and 300 of such genes, that is to say, those that would have the region holding regulatory signals removed. This is precisely the region where microRNAs -- small molecules regulating the translation of this RNA to protein -- bind. "Many antitumor therapies attempt to interfere with microRNA binding, but we have now revealed that CPEB proteins remove these regions beforehand. The pharmaceutical companies that are developing such compounds will be able to predict whether their targets are suitable approaches or not," explains the scientist.

The study has involved the collaboration of the group led by Juan Valc?rcel at the Center for Genomic Regulation (CRG), an expert in RNA nuclear processing, and that of Roderic Guig?, an expert in biostatistics and also at CRG. This study received funding from the Consolider RNAreg consortium of the Spanish Ministry of Economy and Competition and the Generalitat de Catalunya (Government of Catalonia).

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Story Source:

The above story is reprinted from materials provided by Institute for Research in Biomedicine (IRB Barcelona).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Felice-Alessio Bava, Carolina Eliscovich, Pedro G. Ferreira, Belen Mi?ana, Claudia Ben-Dov, Roderic Guig?, Juan Valc?rcel, Ra?l M?ndez. CPEB1 coordinates alternative 3?-UTR formation with translational regulation. Nature, 2013; DOI: 10.1038/nature11901

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/6AD_azErazs/130224142827.htm

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Cycles in Action ? Automotive Rendering | BlenderNation

I always enjoy watching Cycles rendering. In this short video, eMirage shows Cycles at work in rendering a car.

eMirage writes:

A quick video showcasing the power of blender?s render engine (Cycles) in automotive rendering.

The purpose of this demo is to show you how practical cycles is, and how much it helps to quickly set shaders / material colors, change the lighting and set the render views

The video playback run slightly faster than normal speed, but you can see the real render times in the top of the render view ?elapsed? (expressed in fraction of seconds)
the playback runs faster because it was recorded at 20i/s and plays at 24i/s

Used hardware spec (GPU rendering):

CPU: intel core i7 2600 3.5GHz ? RAM: 16Gb
GPU: Geforce GTX285 as a display device
2x Geforce GTX580 as CUDA compute devices

follow my works and stay tuned, thanks :)

Link

This entry was posted in Video by Community Reporter. Bookmark the permalink.

Source: http://www.blendernation.com/2013/02/24/cycles-in-action-automotive-rendering/

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CrunchWeek: Sony?s PlayStation 4 Madness; Google?s Big Hardware Week And Albumatic?s Launch

It?s time for CrunchWeek, the TechCrunch TV show where a few of us writers take a look back at the past seven days and talk about a few of the week?s most interesting stories.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/38AZ-kTJhUI/

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Jason Steidl: The Scandal of Catholicism and the Lesson to Learn From It

Recent reports by Italian media are heaping fuel onto the fire of rumors raging around the scandal-laden Vatican bureaucracy. According to La Repubblica, Pope Benedict's recent and shocking resignation stemmed in part from his frustrations over entrenched corruption and the wide-ranging influence of a network of gay Vatican officials operating within the hierarchy. The news comes at a time of transition for the institution, whose powerful College of Cardinals is preparing to meet soon in a secret conclave to elect the next pope.

The details of the story from La Repubblica are vague yet intriguing. According to undisclosed sources, a recent commission report on the Vatileaks scandal read only by the pope concluded that high-ranking church officials were being blackmailed by those with whom they had "ties of worldly nature." Though La Repubblica's description of these relationships is unclear, the article alludes to transgressions against the Biblical commandments "Non fornicare, non rubare" -- "thou shalt not commit adultery" and "thou shalt not steal."

Whether La Repubblica's report is true or false remains to be seen. Vatican Secretary of State Cardinal Tarcisio Bertone -- himself a possible, though controversial, candidate for the papacy -- has strongly denied the story, deploring the accusations as groundless media attempts to smear Vatican officials and improperly influence the papal conclave. Whatever the truth of La Repubblica's reporting, however, there is no question that this account of Vatican corruption is an explosive topic in the media, increasing the scrutiny of an institution already mired in rumors of conspiracy and vice. The story titillates and incorporates elements of the best harlequin novels -- sex, power, secrecy, hypocrisy, greed.

Some Catholics may come to the defense of the institutional church, claiming that the media is inherently biased against the faith. In opposition to a hostile world these Catholics defend the current pope as an innocent, if na?ve, defender of Christianity and the Vatican as a God-ordained, if human, organization unwaveringly following its founder, Jesus Christ.

As a Roman Catholic, I don't deny the church's claims to be a guardian of Christian belief. The institutional hierarchy plays an important role defining and sharing the faith with the world. As a realist, however, I also recognize that the church is characteristically human. Scandal has been a part of the Catholic Church from its start. Peter, the first pope, publicly denied Christ three times, renouncing the savior in his hour of darkest need. Later popes didn't fare much better. As many authors have pointed out, the Roman Church has throughout time been a source of sin and scandal for the faithful. Dante's Inferno famously portrays Hell as a place populated with pontiffs eternally damned for their offenses. More recently, the sex abuse scandal has rocked the world by uncovering the depths of depravity within the heart of the church. The Vatileaks scandal continues to reveal corruption at the center of the papal household and an ecclesial administration often far more concerned with personal gain and power than charity and service. The church seems a hypocrite. Though it preaches holiness, it lives in sin. Though it claims access to divine truths, it wallows in wanton debauchery.

How, then, is the scandalized Christian to respond to a church so clearly comprised of the vilest sinners? What should our reactions be to the rumors of sex and greed and lies and power-mongering and cover-ups? First, I suggest, we shouldn't be surprised. As experience has shown and Christian faith has taught, people are sinners and make mistakes. The world is a broken, messed up place, and no one -- not even the pope himself -- is exempt from sin's effects. As the scriptures make clear, every human being has fallen short of God's purposes. We are all in this mess of a world together and no one is innocent. To pretend that the leaders of the institutional church are somehow different than the rest of us is to deny Christian claims that sin is universal and its effects are pervasive.

It is for this reason, however, that Christian faith proclaims God's mercy and free gift of salvation. In the midst of human brokenness only God's love can restore human nature and only divine grace can fix the bad condition we share. Wrongdoing in our lives and in the church reveals to us how greatly in need of the Christian Gospel we are. It is because we are all touched by and contribute to the fallen state of things -- because it penetrates our souls and reaches into the deepest places of our collective institutions -- that we need someone to come rescue us from our self-initiated destruction. Christian faith claims that this savior was Jesus Christ, and that he made a way to right relationship with God and the world through his life on earth, death on the cross, and triumph through the resurrection. The Catholic Church knows the hope for salvation is necessary precisely we have known the terrible effects of our painful state.

During Lent, Christians take time in preparation for Easter to consider human nature and the condition of sin. We realize that our actions have betrayed a world that God intended for our best. Our relationships with each other, God, ourselves, and the world are disordered and distressing. We do not love as we should love, and we fail time and time again to contribute to God's good purposes on earth. For this reason, during Lent church sanctuaries and priestly vestments are bedecked in purple, a sign recognizing collective sin and confessing that the institutions and leaders of faith are themselves part of the problem. As we prepare for the celebration of Easter, Christians would do well to remember that belief in God's triumph over sin presupposes the constant presence of a dark, wounded nature within and around us. Scandals at the Vatican remind us that the faith in redemption we share is a message which we and the world need to hear.

?

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Source: http://www.huffingtonpost.com/jason-steidl/the-scandal-of-catholicism-and-the-lesson-to-learn-from-it_b_2752144.html

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Expired SSL certificate causes Microsoft Azure outages ? SlashGear

Sorry, Readability was unable to parse this page for content.

Source: http://theglobalvillageweb.com/news/expired-ssl-certificate-causes-microsoft-azure-outages-slashgear/

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Guam's Solving Its Snake Problem With a Horrifying Rain of Poisoned Mouse Paratroopers

Guam has a problem with brown tree snakes. Specifically, it has two million brown tree snakes, and they're slowly decimating the country's other native species. So scientists have come up with a solution, the only logical one really: fill a bunch of dead mice with painkillers, give each corpse a tiny parachute, and throw them all out of helicopters into the jungle. No but really. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/7BqEhNHrzPI/guams-solving-its-snake-problem-with-a-horrifying-rain-of-poisoned-mouse-paratroopers

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Top Smartphone OEMs 3 Month Avg. Ending Dec. 2012 vs. 3 Month Avg. Ending Sep. 2012 Total U.S. Smartphone Subscribers Age 13+ Source: comScore MobiLens
?	Share (%) of Mobile Subscribers
	Sep-12	Dec-12	Point Change
Total Mobile Subscribers	100.0%	100.0%	N/A
Apple	34.3%	36.3%	2.0
Samsung	18.7%	21.0%	2.3
HTC	12.0%	10.2%	-1.8
Motorola	9.8%	9.1%	-0.7
LG	6.6%	7.1%	0.5

?

Top Smartphone Platforms 3 Month Avg. Ending Dec. 2012 vs. 3 Month Avg. Ending Sep. 2012 Total U.S. Smartphone Subscribers Ages 13+ Source: comScore MobiLens
?	Share (%) of Smartphone Subscribers
	Sep-12	Dec-12	Point Change
Total Smartphone Subscribers	100.0%	100.0%	N/A
Google	52.5%	53.4%	0.9
Apple	34.3%	36.3%	2.0
Blackberry	8.4%	6.4%	-2.0
Microsoft	3.6%	2.9%	-0.7
Symbian	0.6%	0.6%	0.0

?

• 

  iPhone 5 has arrived... and in
  1. FaceTime: Live video
  3. Multitasking: Run more then
  4. Retina Display: With 3.5 inch
  
  

• 

  iOS 6 App Development

  1. Multitasking allow Apps to perform
  2. iAD integration with iPhone App will earn more
  3. Developers preview of GameKit API to work r

• 

  iPhone Books Publishing

  eBooks publishing on iPhone
  1. Unlimited Pages
  2. Easy to navigate and read
  3. Easy to download
  4. Page fli
  5. Search through book

• 

  Apple iPhone has
  1. Entertainment Application
  2. Travel Applications
  3. Eductaion Applications
  4. Medical Applications
  5. Sports Applicatons

• 

  Developing a successful
  1. Industry best resources.
  2. Multiple communication channels
  3. Flexible working models to work with.
  4. Pay for only working hours.
  5. 100% confidentiality

Source: http://www.dzoapps.com/overview.php

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Apple Theft Is So Bad That the NYPD Has a Dedicated iTheft Division

It should come as no surprise that iPhones and iPads are prime targets for theft, but it's gotten really bad in New York City. It's so bad that, according to the New York Post, the NYPD is setting up a unit specifically to handle iDevice theft and work with Apple to track down the thieves. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/BpIYmqHKqZI/apple-theft-is-so-bad-that-the-nypd-has-a-dedicated-itheft-division

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What sequester says about who's controlling the Republican Party

Since losing the White House in November, the Republican Party has been going through a very public period of "soul searching," wrestling with what the party stands for and how to broaden its appeal in future elections. Mostly, that struggle has been cast as a fight between the tea party and what's loosely referred to as "the establishment."

In reality, it's more complicated than that, of course. The GOP, just like its Democratic counterpart, is a messy compilation of a variety of factions ? social conservatives, antitax and small-government crusaders, defense hawks, and a hodgepodge of single-issue voters (gun enthusiasts, for example) ? all of whom have different, and sometimes conflicting, priorities.

Now, the battle over the ?sequester? ? the automatic cuts to defense and non-defense discretionary spending scheduled to hit at the end of next week ? is highlighting one of those intraparty fights in a big way, by pitting the GOP's defense hawks directly against its antitax crusaders.

RECOMMENDED: Pentagon's budget nightmare: How each branch would handle sequester cuts

And so far, it's pretty clear who's winning.

As Time's Michael Crowley writes: "With the sequester scheduled to inflict $46 billion in cuts to the Pentagon budget, President Obama has offered an alternative that would mitigate the cuts, in part, by raising taxes on the wealthy. But Republican leaders won?t swallow any new taxes or accept smaller cuts to the federal budget. And so, defense will get the budget ax. And national security conservatives, long accustomed to being granted virtually every wish by their party, find themselves appalled."

The GOP's national security conservatives have made it clear they believe the sequester is not just bad policy, but extremely dangerous. Sen. John McCain (R) of Arizona recently called it "outrageous and shameful," saying it "impairs the ability to defend our nation in these very tense times with great challenges to our national security."

Want your top political issues explained? Get customized DC Decoder updates.

By contrast, the antitax wing of the party has lately been arguing that the sequester will be no big deal ? and, in fact, doesn't go nearly far enough. Sen. Rand Paul (R) of Kentucky, a tea party conservative who tends to be skeptical when it comes to foreign intervention, told CNN this week that the sequester was a mere "pittance," pointing out that it will only slow the rate of growth of spending, while spending overall will continue to increase. The likely impact of the cuts, according to Senator Paul, "will be in some ways a yawn."

Now, it's true that the antitax wing of the party suffered a defeat of its own a few months back when Republicans agreed to raise taxes as part of a deal to resolve the "fiscal cliff" (putting the sequester off for three more months). But it seems that battle has made them even more determined to win this time around.

At the same time, the relative diminution of the pro-defense wing of the party may have been inevitable ? in part, because of the legacy of the Bush years. The GOP's defense hawks are now primarily associated with the unpopular war in Iraq and unpopular public figures like former Vice President Dick Cheney. In fact, frustration with the Bush administration's willingness to spend huge sums of public money on wars and other foreign interventions (as well as on new domestic spending, like the Medicare prescription drug plan) was a primary factor in the creation of the tea party.

The sequester itself may still be resolved at some point ? if not before it officially hits next week, then perhaps in subsequent weeks as its effects begin to play out. But the impact of this particular battle on the internal dynamics of the Republican Party ? particularly if it establishes the antitax wing as dominant above all others going forward ? could be much longer-lasting.

RECOMMENDED: Pentagon's budget nightmare: How each branch would handle sequester cuts

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Source: http://news.yahoo.com/sequester-says-whos-controlling-republican-party-191735956.html

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