Yahoo to acquire Tumblr for $1.1 billion cash

LONDON, May 18 (Reuters) - Manchester United's outgoing manager Alex Ferguson has criticised neighbours Manchester City for sacking Roberto Mancini. The Italian boss was sacked on Monday having failed to retain the Premier League title he won last season and after losing the FA Cup final to Wigan Athletic. Mancini took out a full-page advertisement in the Manchester Evening News on Saturday, thanking fans for their support during his time in charge. ...

Source: http://news.yahoo.com/yahoos-board-approves-1-1-billion-tumblr-acquisition-103611211.html

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RNA capable of catalyzing electron transfer on early earth with iron's help, study says

RNA capable of catalyzing electron transfer on early earth with iron's help, study says

Monday, May 20, 2013

A new study shows how complex biochemical transformations may have been possible under conditions that existed when life began on the early Earth.

The study shows that RNA is capable of catalyzing electron transfer under conditions similar to those of the early Earth. Because electron transfer, the moving of an electron from one chemical species to another, is involved in many biological processes ? including photosynthesis, respiration and the reduction of RNA to DNA ? the study's findings suggest that complex biochemical transformations may have been possible when life began.

There is considerable evidence that the evolution of life passed through an early stage when RNA played a more central role, before DNA and coded proteins appeared. During that time, more than 3 billion years ago, the environment lacked oxygen but had an abundance of soluble iron.

"Our study shows that when RNA teams up with iron in an oxygen-free environment, RNA displays the powerful ability to catalyze single electron transfer, a process involved in the most sophisticated biochemistry, yet previously uncharacterized for RNA," said Loren Williams, a professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology.

The results of the study were scheduled to be published online on May 19, 2013, in the journal Nature Chemistry. The study was sponsored by the NASA Astrobiology Institute, which established the Center for Ribosomal Origins and Evolution (Ribo Evo) at Georgia Tech.

Free oxygen gas was almost nonexistent in the Earth's atmosphere more than 3 billion years ago. When free oxygen began entering the environment as a product of photosynthesis, it turned the earth's iron to rust, forming massive banded iron formations that are still mined today. The free oxygen produced by advanced organisms caused iron to be toxic, even though it was ? and still is ? a requirement for life. Williams believes the environmental transition caused a slow shift from the use of iron to magnesium for RNA binding, folding and catalysis.

Williams and Georgia Tech School of Chemistry and Biochemistry postdoctoral fellow Chiaolong Hsiao used a standard peroxidase assay to detect electron transfer in solutions of RNA and either the iron ion, Fe2+, or magnesium ion, Mg2+. For 10 different types of RNA, the researchers observed catalysis of single electron transfer in the presence of iron and absence of oxygen. They found that two of the most abundant and ancient types of RNA, the 23S ribosomal RNA and transfer RNA, catalyzed electron transfer more efficiently than other types of RNA. However, none of the RNA and magnesium solutions catalyzed single electron transfer in the oxygen-free environment.

"Our findings suggest that the catalytic competence of RNA may have been greater in early Earth conditions than in present conditions, and our experiments may have revived a latent function of RNA," added Williams, who is also director of the RiboEvo Center.

This new study expands on research published in May 2012 in the journal PLoS ONE. In the previous work, Williams led a team that used experiments and numerical calculations to show that iron, in the absence of oxygen, could substitute for magnesium in RNA binding, folding and catalysis. The researchers found that RNA's shape and folding structure remained the same and its functional activity increased when magnesium was replaced by iron in an oxygen-free environment.

In future studies, the researchers plan to investigate whether other unique functions may have been conferred on RNA through interaction with a variety of metals available on the early Earth.

In addition to Williams and Hsiao, Georgia Tech School of Biology professors Roger Wartell and Stephen Harvey, and Georgia Tech School of Chemistry and Biochemistry professor Nicholas Hud, also contributed to this work as co-principal investigators in the Ribo Evo Center at Georgia Tech.

###

Georgia Institute of Technology: http://www.gatech.edu

Thanks to Georgia Institute of Technology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128307/RNA_capable_of_catalyzing_electron_transfer_on_early_earth_with_iron_s_help__study_says

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Steve Mariotti: The Best and the Brightest -- My Favorite Book

Everyone has a favorite book. I read The Best and the Brightest by David Halberstam over and over again, at least once a year. Sometimes, I will pick it up to touch and feel it, reading just a page or two, knowing by heart whole sections.

It took three years for David to research and another two years to write. Finally published in 1972, it tells the tale of the Vietnam tragedy of how the United States went from 15,000 troops in 1962 to over 500,000 soldiers by 1968, spending trillions of dollars in the process and losing over 50,000 American lives.

Arguably, Vietnam was the biggest tragedy for the U.S. since the Civil War. Halberstam was fascinated by Vietnam having won a Pulitzer for his writings on the war early on in '62. So irritated with his questioning of our policy, President Kennedy called Sulzberger, the owner of the New York Times, to ask that the young David be reassigned.

David began his masterpiece with a trip to Saigon in 1967 to cover the escalating war for Harper's. Given the opportunity to write as much as he wanted with an unlimited time limit, he eventually turned the article into a 652 page book -- perhaps the greatest non-fiction political analysis ever written. In my opinion, David Halberstam is the greatest journalist of the last 100 years.

Writing and researching 10 hours a day, David finally finished and the book became an instant best seller with awesome critical reviews as well. I first read the book in 1977 when I had just fulfilled a lifelong dream and became a part of Ford Finance Staff, the legendary group that ran Ford Motor Company and had been created by Bob McNamara, the main character in Halberstam's book. Ford Finance was located on the 10th and 11th floors of Ford World Headquarters located in Dearborn, Michigan, and my office was on the 10th floor in Room 1036, the area of international finance.

Ford Finance staff produced more CEOs of Fortune 500 firms than any other organization other than Harvard Business School. It was clearly the greatest finance department in American business and had done so much to build modern management techniques. It had been developed by the Whiz Kids -- a group of elite Air Force officers who were brought to Ford by Henry Ford in 1946 to help save the company by bringing in advance management techniques.

I highly recommend the book The Whiz Kids for background on this interesting story. The Whiz Kids were spectacularly successful in turning around Ford and much of their success was because of Bob McNamara and my own boss, Edward J. Lundy, the Senior Vice President of Finance.

Bob had become president of Ford in 1960 before being named by President Kennedy to head up the Department of Defense -- becoming the foolish protagonist in Halberstams book.

Halberstam had written over 10 pages on Ford Finance Staff, capturing our culture brilliantly; and in my second year firmly entranced as the treasury analyst of Ford South Africa and Ford Aerospace, Ford Venezuala and Ford Mexico, I made 40 copies of the 10 pages and distributed them to senior finance staff members.

Everyone was quite pleased as Halberstam had brilliantly captured how we felt about ourselves -- The Best and the Brightest. The legendary Lundy called me himself -- by then, I was called "Stevie Wonder" -- to say: "Awesome job, Steve. Great for morale. Although, I felt Bob got a bad rap on Vietnam. It was those generals that gave him bad advice." Not wanting to express my own opinion, I said, "Yes sir, Mr. Lundy, there was a lot of blame to go around."

At Ford, we used tape recordings in our personal meetings. We taped and then listened to people talk in what was called 'face offs.' It was part of our culture and we were proud of it. Finance staff faceoffs were daily through out world headquarters -- like massive therapy sessions, everyone voice was heard literally. Not only was listening and analyzing conversations part of our culture, but we made a lot of the equipment for suvailance at our division, Ford Aerospace, for which I was the financial analyst in the Treasurers Department.

As I was the analyst for both Ford Aroespace and Ford South Africa, I would review the agreement to sell surveillance equipment to places like the South African government.

I though that it was immoral to be helping a totalitarian racist regime and began under the tutelage of Reverend Sullivan, a legendary African-American political activist, to change Ford policy, coming up with guidelines on who we could sell to, prohibiting us from selling to corrupt governments. But that is a story for later so back to my tale of meeting Halberstam...

After I left Ford, I moved to New York City seeking fame and fortune. My plan was to call all the people I had read about in Michigan and go see them. My first call was to Halberstam.

"I think your book is brilliant. I was at Ford and we loved it." I said eagerly.

"Thank you Steve. Any feedback?" he asked. I could not resist." I was curious as to why you never mentioned anything about the use of surveillance at the company. We made all the equipment and sold it around the world, but it was always first tested at Ford world headquarters by Henry himself."

I could see him through the phone, aghast. He thought I was a kook. Feeling uncomfortable, he quickly got off the phone, and I was deeply hurt and embarrassed.

But time and truth were on my side. In 1982, Lee Iacocca published his book, Iacocca. Brilliantly written, it became a bestseller, and everyone was reading it. Sure enough, on page 117, Lee wrote about what I had seen, took part in and told David Halberstam about -- the use of surveillance equipment at Ford.

Lee wrote openly that we made the equipment and Henry Ford himself would test it by seeing if he could hear what was going on in Lee Iacocca's office when he went out to lunch about a mile a way.

Vindicated, I got a copy of the book, marked page 117, and sent a note on top to Mr. Halberstam saying, "here is some investigative research on the issue of surveillance at Ford motor company which we discussed." Probably not one of my finer moments, but it made me feel better to set the history straight. Soon after my phone rang and I picked up.

"Steve Mariotti, it is David Halberstam. You were right about the tapes and I wish I had written about it. How about lunch?"

The very next day in 1982, we feasted at his favorite place, the Harvard Club, and he told me in great detail about writing the first draft of The Best and the Brightest. It was the funniest lunch I have ever had.

We stayed friends for the next 15 years until his tragic auto accident in California.

David Halberstam truly was one of The Best and the Brightest.

?

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Source: http://www.huffingtonpost.com/steve-mariotti/the-best-and-the-brightes_1_b_3309299.html

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BrandYourself Upgrades Its Online Reputation Tools With A Full-Service Concierge Feature

BrandYourself is expanding its efforts to take on the big names in the online reputation market (particularly Reputation.com) with the launch of a new version of its service. The company started out as a fairly simple self-service tool for trying to improve your presence online, for example by creating a website and other content to push down undesirable results when someone Googles your name. (It has become increasingly focused on Google results over time.) The basic service is free, but BrandYourself charges $10 a month for additional features and usage.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/8CNOqvZSXP0/

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Mechanism linking key inflammatory marker to cancer identified

May 20, 2013 ? In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.

Scientists call this Jekyll-and-Hyde molecule NF-kappa B. In healthy cells, it is a powerful "first responder," a vital part of the body's immune and inflammatory responses. It spends most of its life in the cell's cytoplasm, quietly awaiting orders. But when extracellular signals -- of a viral or bacterial invasion, for example -- set off chemical alarms, the cell unchains this warhorse, allowing it to go into the nucleus where it spurs a flurry of defensive activity, including the transcription of genes that trigger inflammation, promote cell proliferation and undermine cell death.

Researchers have known for years that a hyperactive form of NF-kappa B that gets into the nucleus and stays there is associated with various cancers. But they didn't know what was keeping it active in the nucleus.

"Normally in the cell NF-kappa B is in the cytosol, it's not in the nucleus, and it's not activated," said University of Illinois medical biochemistry professor Lin-Feng Chen, who led the new study. "You have to stimulate normal cells to see NF-kappa B in the nucleus. But in cancer cells without any stimulation you can see this nuclear form of NF-kappa B. The cell just won't die because of this. That is why NF-kappa B is so important in cancer."

In the new study, Chen's group found that another molecule known to help regulate gene expression, called BRD4, recognizes a specific amino acid on a subunit of the NF-kappa B protein complex after the amino acid has been marked with a specific tag, called an acetyl group. This "acetylation" allows the BRD4 to bind to NF-kappa B, activating it and preventing its degradation in cancer cells.

Previous studies had shown that BRD4's recognition of the acetylated subunit increased NF-kappa B activation, but this recognition had not been linked to cancer.

BRD4 belongs to a class of molecules that can recognize chemical markers on other proteins and interact with them to spur the marked proteins to perform new tasks. Chemical "readers" such as BRD4 are important players in the field of epigenetics, which focuses on how specific genes are regulated.

"In epigenetics, there are writers, there are readers and there are erasers," Chen said. The writers make modifications to proteins after they are formed, without changing the underlying sequence of the gene that codes for them. These modifications (such as acetylation) signal other molecules (the readers) to engage with the marked proteins in various ways, allowing the proteins to fulfill new roles in the life of the cell. Epigenetic erasers remove the marks when they are no longer of use.

Such protein modifications "have been shown to be critically involved in transcription regulation and cancer development," the researchers report.

To test whether BRD4 was contributing to the sustained presence of NF-kappa B in the nucleus of cancer cells, Chen and his colleagues exposed lung cancer cells in cell culture and in immune-deficient mice to JQ1, a drug that interferes with BRD4 activity. Exposure to JQ1 blocked the interaction of BRD4 and NF-kappa B, blocked the expression of genes regulated by NF-kappa B, reduced proliferation of lung cancer cells and suppressed the ability of lung cancer cells to induce tumors in immune-deficient mice, the researchers found.

The researchers also discovered that depletion of BRD4 or the treatment of cells with JQ1 induced the degradation of the NF-kappa B subunit recognized by BRD4.

Chen said that BRD4 likely prevents other molecules from recognizing the hyperactive NF-kappa B in the nucleus and marking it for degradation.

"This is an example of how epigenetic regulators and NF-kappa B may one day be targeted for the treatment of cancer," he said.

Researchers from Illinois biochemistry professor Satish Nair's laboratory and from the laboratory of James Bradner at the Dana-Farber Cancer Institute contributed to this study.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/gX3-B62y22w/130520095320.htm

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Nora Ephron Quotes To Get You Through A Breakup (PHOTOS)

The late Nora Ephron put her keen knack for observation to use in essays, novels and beloved screenplays (think "When Harry Met Sally," "Sleepless in Seattle," and more).

But as far as we're concerned, Ephron, who died in June 2012, was at her best whe writing about the heartbreak -- and the eventual healing -- that comes after a split. (It's not for nothing that Ephron served as HuffPost Divorce's editor-at-large.)

To celebrate Ephron's birthday on May 19, we've compiled six of our favorite quotes from the late writer on nursing a broken heart. Scroll down to read them all, then share your favorite quote from Ephron -- whether it's from a movie or a book -- in the comments.

1.

2.

3.

4.

5.

6.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/05/19/nora-ephron-quotes-_n_3294898.html

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How Much the Starship Enterprise Costs, Google I/O Goodies, And More

It's been a big, big week. Google I/O hit this week, bringing along a whole bunch of Android updates, if not a new version or any actual hardware. And aside from all that jazz, we've got an ode to Chris Hadfield, (a wild guess at) how much it would cost to build the starship Enterprise, why 3D-printing is overrated, the best streaming radio service, why your ears pop on an airplane and more.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/5TJIUTWtE9k/how-much-the-starship-enterprise-costs-google-i-o-good-508290319

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Come Mr. HR man, hire my alumni (rent check due soon, don?t wanna lose home) (Unqualified Offerings)

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Yet Another TechCity Report Confuses Tech Companies With Web Agencies And Consultants

A new report commissioned by research giant GfK claims that the growth of the high density cluster of technology companies in East London (dubbed Tech City by the UK government) is being "stunted" by a talent shortage and lack of access to capital. The ?Tech Futures Report' - commissioned by publishing company TechCityInsider and sponsored by accountant Grant Thornton, recruitment firm Vitamin T, City University London and Digital Shoreditch is based on 141 interviews of 'tech' company senior management. In fact, only less than half of these admitted to developing technology products and platforms. It's simply the latest in a long line of reports that conflate consultants and digital advertising agencies with technology companies, leading to yet more confusion about the state of the cluster.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/bZLZSyf51Cg/

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Nigeria military declares 24-hour curfew in city

MAIDUGURI, Nigeria (AP) ? Nigeria's military declared a 24-hour curfew Saturday on neighborhoods in a northeastern city that's the spiritual home of an Islamic extremist network as soldiers continued the government's emergency campaign in the region, with authorities saying they killed 10 suspected insurgents.

A statement Saturday on behalf of Lt. Col. Sagir Musa named 11 areas of Maiduguri where people must remain inside their homes until further notice. Musa said it was part of the military's push since President Goodluck Jonathan issued an emergency decree Tuesday allowing soldiers to arrest people at will and take over buildings suspected to house extremists in Adamawa, Borno and Yobe states.

Soldiers arrested some 65 suspected extremists who were "attempting to infiltrate Maiduguri" after military strikes on camps in a nearby forest reserve, military spokesman Brig. Gen. Chris Olukolade said in a statement Saturday. Olukolade said soldiers killed another 10 suspected extremists in Maiduguri's Gamboru neighborhood, one of the areas now under curfew.

There was no independent confirmation of the arrests nor the killings. An Associated Press journalist in Maiduguri saw roadblocks manned by soldiers in the city, as well as trucks lined up outside the city, apparently blocked by the military from entering.

Maiduguri, the capital of Borno state, once was home to the main mosque of Boko Haram. Nigeria's Islamic extremist insurgency grew out of a 2009 riot led by Boko Haram members in Maiduguri that ended in a military and police crackdown that killed some 700 people. The group's leader died in police custody in an apparent summary execution, fueling dissent that broke into the open in 2010 with the targeted killings of government officials, security agents and religious leaders who spoke out against the sect. The killings gradually morphed into the large-scale extremist network that is plaguing Nigeria today.

Soldiers backed by jet fighters and military helicopters have flooded into the northeast since Jonathan's order Tuesday. On Thursday, soldiers attacked suspected camps sheltering insurgents in a forest reserve south of Maiduguri. At least 21 suspected extremists died in the attack, an official told the AP on Friday. The military said it destroyed the extremists' equipment and gasoline supplies.

On Saturday, Olukolade asked the public to inform authorities if they saw anyone attempting to gather large quantities of gasoline.

"Some of the fleeing insurgents from various camps have been noted to be in search of fuel," the brigadier general said.

This new military campaign comes on top of a previous massive deployment of soldiers and police to the region. That deployment failed to stop violence by Islamic extremists, who have killed more than 1,600 people since 2010, according to an AP count. It also has seen soldiers arrest, torture and even kill civilians.

Boko Haram, whose name means "Western education is sacrilege" in the Hausa language of Nigeria's predominantly Muslim north, has said it wants to establish an Islamic state in Nigeria and wants the government to release all of its imprisoned followers. Boko Haram has sparked splinter groups like Ansaru, which has kidnapped foreign hostages. Analysts and diplomats also say the network has loose ties to two other al-Qaida-influenced groups on the African continent.

___

Associated Press writer Bashir Adigun in Abuja, Nigeria, contributed to this report.

___

Jon Gambrell reported from Yenagoa, Nigeria, and can be reached at www.twitter.com/jongambrellAP .

Source: http://news.yahoo.com/nigeria-military-declares-24-hour-curfew-city-151432766.html

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Friday random ten: The city never sleeps, part 6 (Offthekuff)

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Sociologist Lyn Spillman Awarded Two Book Prizes // News ...

Lyn Spillman, a professor in Notre Dame?s Department of Sociology, has been awarded two book prizes from the American Sociological Association for her work Solidarity in Strategy: Making Business Meaningful in American Trade Associations (University of Chicago Press).

The Mary Douglas Prize honors the best book in the field of cultural sociology, and the Viviana Zelizer Award recognizes the best book in economic sociology.

Winning ?best book? awards in both economic sociology and cultural sociology is no easy feat, says Professor Rory McVeigh, department chair. ?It is not unlike producing a spirit of bipartisanship in Congress. It takes extraordinary scholarship to bridge these two fields of study so effectively.

?While winning these two awards is very impressive, I am quite certain that this is just the beginning in terms of awards and recognition for Solidarity in Strategy,? he adds. ?This is one of those rare books that people will still be reading and discussing in sociology graduate seminars 50 years from now.?

Exploring New Territory

Solidarity in Strategy is one of the first in-depth explorations of the role of trade associations in economic culture.

Supported by a Guggenheim Fellowship, Spillman compiled her own database of more than 4,400 associations. She then chose 25 groups to study further, collecting information about their activities and analyzing their business culture from multiple points of view.

According to Spillman, the function of trade associations is much more collegial than cutthroat. The primary focus of these disparate groups?including the Academy of Motion Picture Arts and Sciences and the International Concrete Repair Institute?is to promote camaraderie, professionalism, and sociability. Her findings challenge the idea that capitalism is motivated solely by the pursuit of profit and self-interest.

?Even at the heart of capitalist business, culture is important,? she says. ?A purely strategic approach isn?t sustainable.?

Affecting Economic Outcomes

Spillman has long been intrigued by economic sociology, she says. ?As a sociologist, I?m struck by the fact that economic actions like working, buying, selling, saving, and giving are a fundamental part of everyday life. All spheres of society, from family to religion to politics, involve economic action, and social groups can affect economic outcomes.?

The financial crisis in 2008 brought a new wave of interest to the growing field, she says.

Capitalizing on that interest and drawing on her research for Solidarity in Strategy, Spillman designed and began teaching a new undergraduate class on economic sociology. ?There is always great discussion in that class, and a nice mix of students, including business and economics majors as well as sociology majors.?

Spillman also brings her research into courses on cultural sociology, her primary area of interest and expertise. ?Now, when I teach that,? she says, ?I include a whole new topic?economic life?to explore how and why culture is important.?

Contributing to Two Fields

Spillman is continuing her work in economic sociology with two new research initiatives. One project, which builds on a theme from her book, explores how culture influences the degree to which people are driven by profit and self-interest.

The other project examines how the media presents economic issues. ?I?m working together with a group exploring the norms and values that emerge when topics like foreign investment, financial innovations, corporate social responsibility, and inequality are discussed in the media,? she says.

In August, Spillman will attend the American Sociological Association?s annual meeting, where she will be presented with both prizes for Solidarity in Strategy.

?I?m thrilled and honored to win these awards,? she says. ?I am a cultural sociologist first and foremost and wanted to make a contribution to both cultural and economic sociology.

?Economic sociology is such an exciting field right now, and the recognition of my colleagues really means a lot.?

with contributions from Sara Burnett

Learn More >

Source: http://al.nd.edu/news/40069-sociologist-lyn-spillman-awarded-two-book-prizes/

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Promising treatment for progeria within reach

Friday, May 17, 2013

"This study is a breakthrough for our research group after years of work. When we reduce the production of the enzyme in mice, the development of all the clinical symptoms of progeria is reduced or blocked. We have also studied cultured cells from children with progeria, and can see that when the enzyme is inhibited, the growth of the cells increases by the same mechanism as in mouse cells," says Martin Berg?, Professor at the Sahlgrenska Academy, University of Gothenburg and research director at the Sahlgrenska Cancer Center.

Progeria is a rare genetic childhood disorder characterized by the appearance of accelerated aging. The classical form of progeria, called Hutchinson-Gilford Progeria Syndrome (HGPS), is caused by a spontaneous mutation, which means that it is not inherited from the parents.

Children with HGPS usually die in their teenage years from myocardial infarction and stroke.

The progeria mutation occurs in the protein prelamin A and causes it to accumulate in an inappropriate form in the membrane surrounding the nucleus. The target enzyme, called ICMT, attaches a small chemical group to one end of prelamin A. Blocking ICMT, therefore, prevents the attachment of the chemical group to prelamin A and significantly reduced the ability of the mutant protein to induce progeria.

"We are collaborating with a group in Singapore that has developed candidate ICMT inhibitor drugs and we will now test them on mice with progeria. Because the drugs have not yet been tested in humans, it will be a few years before we know whether these drugs will be appropriate for the treatment of progeria," Martin Berg? explains.

Although there are only a few hundred children in the world with progeria, the disease, children, and research have attracted a great deal of attention.

"The reason is obvious: the resemblance between progeria patients and normally-aged individuals is striking and it is tempting to speculate that progeria is a window into our normal aging process. The children develop osteoporosis, myocardial infarction, stroke, and muscle weakness. They display poor growth and lose their hair, but interestingly, they do not develop dementia or cancer," says Martin Berg?, who is also studying the impact of inhibiting ICMT on the normal aging process in mice.

###

Journal: Science Article title: Targeting Isoprenylcysteine Methylation Improves Disease Phenotypes in a Mouse Model of Accelerated Aging Authors: Mohamed X. Ibrahim, Volkan I. Sayin, Murali K. Akula, Meng Liu, Loren G. Fong, Stephen G. Young, and Martin O. Bergo

University of Gothenburg: http://www.gu.se/english

Thanks to University of Gothenburg for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 16 time(s).

Source: http://www.labspaces.net/128278/Promising_treatment_for_progeria_within_reach

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UFC suspends Nate Diaz for homophobic slur

UFC lightweight Nate Diaz has been suspended by the promotion for using a homophobic slur in a tweet about fellow fighter Bryan Caraway. After Pat Healy lost his UFC 159 Submission of the Night bonus for testing positive for marijuana, the bonus was given to Caraway. Diaz apparently didn't think Caraway should have accepted the money. Apologies for the language he used in the tweet showing on Cagewriter:

I feel bad for pat Healy that they took a innocent mans money and I think the guy who took the money is the biggest Fag in the world ..

? Nathan Diaz (@NateDiaz209) May 16, 2013

He followed that up with a slur against women.

#sorryasslittlebitch

? Nathan Diaz (@NateDiaz209) May 16, 2013

The UFC responded quickly, suspending Diaz as they investigate what their next move is. The promotion issued a statement on the matter.

"We are very disappointed by Nate Diaz's comments, which are in no way reflective of our organization. Nate is currently suspended pending internal investigation and we will provide further comment once the matter has been decided."

Diaz's Mike Kogan manager then responded that Diaz wasn't using a homophobic slur. Instead, he told MMA Junkie that Diaz was using a misogynistic term.

"Guess what? The word [expletive], at least in Northern California, and where Nate is from, means bitch. It means you're a little punk. It has nothing to do with homosexuals at all. So when Nate made the comment that he made, he didn't make it in reference to homosexuals or calling Caraway a homosexual. He just said it was a bitch move."

Calling someone that word isn't OK, either. Kogan's defense of his fighter is completely out of touch with the UFC's fighter code of conduct, which reads that a fighter will be disciplined for "insulting language about a person's ... gender or sexual orientation." Whether it's a misogynistic or homophobic term, fighters are specifically told not to use it by their code of conduct.

Other popular content on Yahoo! Sports:
? Vitor Belfort's long career arouses suspicion
? Mayors to settle differences in the cage
? Pat Healy?s positive drug test costs him $130,000

Source: http://sports.yahoo.com/blogs/mma-cagewriter/ufc-suspends-nate-diaz-homophobic-slur-121332619.html

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Shares fall as Fed officials talk of QE exit

By David Brett

LONDON (Reuters) - The dollar held firm near a 10-month high versus a basket of currencies on Friday and European shares fell after a regional Federal Reserve chief said the U.S. central bank may begin to taper its asset buying this summer.

European shares were down 0.2 percent at 1,242.49, edging further back from five-year highs and following a retreat in Asian stocks and Thursday's late fall on Wall Street, but still on track for a weekly gain.

"The stock market is driven by liquidity and sooner or later this must end," KBC senior economist Koen De Leus said.

"In the near-term a correction would be healthy, but on the whole the market is (still) well supported by the huge amount of liquidity that is pumped into the system by the central banks."

In Asia, MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.4 percent to 479.33.

The German Bund future slipped at the open as some investors booked profits after this week's gains, but expectations central bank policies will remain ultra-easy for months limited losses.

The Bund future FGBLc1 was 4 ticks lower at 145.27 compared with 145.31 at Thursday's settlement, while the dollar rose 0.4 percent to 83.944 versus its currency basket, close to this week's 10-month high of 84.094.

The Fed's quantitative easing programme has helped stabilise the world's largest economy and sent investors scrambling for returns, suppressing bond and cash yields, inflating asset prices and fuelling a global rally in stocks.

San Francisco Federal Reserve Bank President John Williams said on Thursday the Fed could begin easing its monetary stimulus this summer and end bond buying late this year.

Although Williams does not have a vote in the Fed's policy-setting panel this year, his comments weighed on U.S. shares, which have soared to record highs this year, in part because of the Fed's purchases of $85 billion a month in bonds.

A trio of hawkish regional Federal Reserve officials meanwhile called for the U.S. central bank to stop buying mortgage-backed bonds, citing a recent improvement in the housing market.

"The Fed realises the impact that (QE) has on markets and the potential negative impact on risky assets. Therefore they try to prepare the markets a bit for an eventual end," said BNP Paribas Fortis Global Markets head of research Philippe Gijsels.

Source: http://news.yahoo.com/shares-fall-fed-officials-talk-qe-exit-090344531.html

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Analysis of Sony Corporation - FinanceLab

This article is brought by the Finance Lab Investment Panel
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Sony Corporation is a company that has gone through a difficult period the last years with declining financial performance. The management has recognized this fact and they have launched a new comprehensive strategic plan. Is this a potential successful turn-around or is it a company in continuous decline?
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Sony?s financial performance has been declining the last several years. The revenue has fallen with almost 23% the last five years and from 2009-2012 Sony reported a loss. This was first and foremost because of the decline in the revenue but also because of a significant downturn in their margins. In their newly reported results for 2013 they have reported a profit of $458 million. The increase is mainly caused by the depreciation of the Japanese Yen as well as the consolidation of Sony Ericsson AB. So the result is positively affected by nonrecurring gains and it is therefore not representative for the ongoing development.
?
After a comprehensive renewal of the management team followed by a reorganization of the organizational structure Sony Corporation launched a new ambitious strategic plan. Sony Corporation is with their new plan trying to increase the focus on their core strategic business units and reorganizing their broad portfolio of business units. The three new focus areas, where almost 70% of their R&D budget will be allocated, are ?Digital Imaging?, ?Game? and ?Mobile?. In all of these three areas Sony is going to increase the focus on innovation, strengthen their network across product platforms and improve the integration.
?
In addition to this new focus Sony has also initiated a turn-around of their television business. This included a 60% reduction in fixed business costs as well as a 30% reduction in operating costs. This reduction is supposed to be achieved through a thorough overhaul including reducing the model count with 40%. In addition to the reduction in costs they are also targeting innovation and development of new technology such as OLED.
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As a last part of the strategy plan Sony is going to strengthen their already strong position on emerging markets.
?
Broadly speaking we believe that their new strategy includes some good initiatives and they have realized that they have to focus on their core competences. However, we do believe they could have been more ambitious in the restructuring and possibly sold some of their business units such as the ?Entertainment? division. We also do not believe that their competitive positioning is especially attractive and they have to strengthen their competitive advantage if they want to survive in the market. The execution of the strategy plan also involves significant risks and we would like to see more decisive results before we are convinced.
?
Japan is going through tremendous macroeconomic change and there is a lot of risk involved in this process. The expansionary monetary policy has already caused the Japanese Yen to depreciate and it has also led to gains on the stock market. If it will have a permanent effect or not is difficult to predict and it will be very decisive for Sony during the next years as 32% of their revenue comes from their home market.
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The share price has already soared by almost 80% during this year measured in Japanese Yen and we would argue that the stock is currently too expensive. In addition we believe there is significant risk associated with their new strategy plan, their competitive positioning as well as the Japanese economy. This adds up to the fact that we do not see the company at the current moment as an attractive investment.
?

Source: http://www.financelab.dk/2013/05/17/analysis-of-sony-corporation/

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The EPA Could Lose Its Power to Fight Climate Change Before Using It

Advocates of forceful action on climate change have long held a trump card. The primary source of greenhouse gas emissions in the U.S. is coal plants, and ??since the Supreme Court has determined that those emissions are a pollutant ??the EPA is mandated to regulate them. At some point, then, whether whatever president likes it or not, the agency had to make a rule limiting carbon dioxide?emissions.

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But, what the court giveth, the court can rescind in a tightly contested vote. And with a barrage of petitions raining down on a conservative-leaning Supreme Court, it's possible that the EPA's pollution-control mandate could be eradicated well before the threat of climate change is.

RELATED: Sex Lives of Supreme Court Justices

Among large, developed countries, only Australia emits more carbon dioxide per person than the United States. China emits the most overall, of course, but as greenhouse gas polluters, we're still in the top tier. For decades, environmentalists have pushed to cut the country's overall emissions levels, winning a significant victory in 2007 when the Supreme Court ruled in Massachusetts vs. EPA that carbon dioxide was an air pollutant. Under the Clean Air Act, that required that the EPA take action.

RELATED: Should the Supreme Court Grant Ashcroft Immunity?

So far, it hasn't. When Barack Obama came into office, pledging to be the president who oversaw the moment when "the rise of the oceans began to slow,"?advocates hoped he'd move quickly to curb?carbon dioxide?emissions. In 2009, the House passed a measure to institute a market-based system to reduce emissions; it wasn't voted on in the Senate. Last January, Obama called for a similar solution, saying he'd act if the Congress wouldn't. That declaration, however belated, was interpreted as meaning he would ask the EPA to regulate coal-burning plants, even though his staff seemed unprepared to do so.

RELATED: Elena Kagan, Careerist?

While Obama and the EPA have delayed, opponents of regulating greenhouse gas emissions ??largely fossil fuel companies ??have filed a number of challenges to the Court's ruling. To date, they've failed; in both July and December last year, lower courts upheld the EPA's right to regulate. But each lower court decision makes an appeal to the highest court more inevitable. Reuters indicates that a case could arrive at the Supreme Court as soon as this October.

Some of the challengers specifically ask the court to consider overturning Massachusetts v. EPA. They point out that the Clean Air Act, which passed in 1970, was not designed to tackle climate change. At least one brief, by the state of Virginia, challenges the EPA's evaluation of the climate change science that underpinned its decision to regulate greenhouse gases. Others contend the Supreme Court's holding in the 2007 ruling, which specifically addressed automobile emissions, did not give the EPA the authority to issue greenhouse gas rules that affect such a broad cross-section of the economy.

If the justices were to accept one of these broad petitions and side with challengers, they could make it impossible for the EPA to regulate greenhouse gases and could open the door to attacks on the air pollution regulations the agency has formulated for 30 years, according to Dru Stevenson, a law professor at the South Texas College of Law.

That last point is even more alarming. The EPA uses the Clean Air Act as its mandate to regulate air pollution. If the Court says that it can't use the law to regulate carbon dioxide, it will not take long for companies that emit pollution of various types to challenge other Clean Air Act regulations.

RELATED: Supreme Court Weighs Freeing Chinese Muslims

There were two dissenting opinions filed in the five-to-four Massachusetts vs. EPA, written by Chief Justice John Roberts and Justice Antonin Scalia. The make-up of the Court hasn't changed much; there are two new justices ??Sotomayor and Kagan ??who replace two that voted to support the majority opinion. In other words, it's not clear that the Court hearing the case means that the EPA's ability to regulate carbon dioxide emissions will be revoked.

But it's another sign of the lack of progress made in addressing climate change over the last six years. In 2007, a five-to-four vote established a critical tool that the EPA could use to tackle global warming. In 2013 ? without that having happened and facing a much weaker political position ? environmental advocates can only hope to keep that trump card in the deck.

Source: http://news.yahoo.com/epa-could-lose-power-fight-climate-change-using-193905587.html

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Powerball jackpot closing in on another record

DES MOINES, Iowa (AP) ? A little more than a year after three tickets split a world-record lottery prize, the jackpot for Saturday's Powerball drawing was nearing historic territory.

Should nobody pick the correct six numbers, the prize money will roll over to next week's drawing and almost certainly eclipse the $656 million doled out to winners in Illinois, Kansas and Maryland in the Mega Millions game in March 2012.

But the record could fall Saturday night too if a flurry of last-minute ticket purchases pushes the jackpot much above its current $600 million level. Since the previous drawing on Wednesday, it had grown by at least $236 million.

"If there was no chance, you wouldn't do it," said New Jersey attorney Rubin Sinins, who represented five construction workers who claimed a colleague cheated them out of a share of a multimillion-dollar lottery jackpot.

It seems simple enough: Just correctly pick five white balls out of a drum of 59 and one red one out of a drum of 35.

However, the odds of a single $2 ticket hitting the correct combination are about 1 in 175.2 million. That's slightly less likely than randomly drawing the name of one specific female in the United States: 1 in 157 million, according to the last census.

With such an astronomic payoff available for the lucky ticket holder, some buyers are content to settle for just a share of the winnings.

In Houston, city firefighter John Paetow and a dozen of his colleagues kicked in $10 each for the drawing, as they do occasionally when a the stakes soar into the lottery stratosphere.

"With firemen it's a camaraderie thing," said Paetow, 59. "It just makes sense to pool our money; it buys more tickets, gives us a better chance of winning."

Even if Saturday's drawing doesn't top last year's Mega Millions jackpot, it's already the highest in Powerball history, surpassing that game's $587.5 million record set in November 2012.

A major reason for the sales surge is that last month, Powerball landed the nation's most populous state as California joined 42 others that offer the game. California lottery director Robert O'Neill said the state had brought "sunshine and good fortune" to Powerball.

The Multi-State Lottery Association conducts the drawing live Saturday night from Tallahassee, Fla. The balls are weighed and X-rayed, and there are practice runs before the official televised version.

Source: http://news.yahoo.com/powerball-jackpot-closing-another-record-084632540.html

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Death toll rises in Mpumalanga initiation deaths

May 15 (Reuters) - Post positions for the 138th running of the Preakness Stakes, to be run at Pimlico on Saturday (Post Position, Horse, Jockey, Trainer, Odds) 1. Orb, Joel Rosario, Shug McGaughey, even 2. Goldencents, Kevin Krigger, Doug O'Neill, 8-1 3. Titletown Five, Julien Leparoux, D. Wayne Lukas, 30-1 4. Departing, Brian Hernandez, Al Stall, 6-1 5. Mylute, Rosie Napravnik, Tom Amoss, 5-1 6. Oxbow, Gary Stevens, D. Wayne Lukas, 15-1 7. Will Take Charge, Mike Smith, D. Wayne Lukas, 12-1 8. Govenor Charlie, Martin Garcia, Bob Baffert, 12-1 9. ...

Source: http://news.yahoo.com/death-toll-rises-mpumalanga-initiation-deaths-095151997.html

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'We saved the ship': WWII vets from stricken aircraft carrier gather, likely for last time

Terry Pickard / NBC News

Surviving sailors from the USS Franklin hold a reunion at Patriots Point in Charleston on Friday.

By Terry Pickard and Carlo Dellaverson, NBC News

MT. PLEASANT, S.C. -- Two dozen surviving veterans from the World War II aircraft carrier USS Franklin gathered on Friday, probably for the last time, to honor and remember one of the most remarkable naval episodes of the war.

It was before dawn on a late winter morning in 1945 when a Japanese dive bomber dropped two 500 pound bombs on the Franklin. The year-old carrier nicknamed ?Big Ben? was serving in the Pacific theater and, at that moment, had maneuvered closer to Japan than any other U.S.-flagged carrier during the war.

Sam ?Dusty? Rhodes was asleep in the ship?s bunk area when the bombs hit. Rhodes was a water tender 3^rd class and was responsible for operating the ship?s massive boilers ? and with debris from the massive explosions raining down on him, that is just what he did.

Rhodes said he and other crew members ran to the one of the unaffected firerooms and attempted to raise enough steam to light the remaining boiler. When the flame caught from Rhodes? Zippo lighter, ?that?s when the ship?s heart started to beat again,? he recalled.

Above on the flight deck, the scene was nothing short of catastrophic. The Franklin was dead in the water, listing to one side and cut off from communications as fires burned everywhere. More than 800 sailors died in the attack, with hundreds more wounded.

Terry Pickard / NBC News

Flags line the walkway to the USS Yorktown, where a '13' was painted to honor the number of the USS Franklin.

But the Franklin didn?t sink, and that is the legacy crew members like Rhodes like to remember. The Franklin would become the most heavily damaged aircraft carrier of the war to make it back to port.

?We saved the ship,? Rhodes said. ?In the Navy, you save the ship. It?s your home.?

William Schauer was a Naval electrician and fireman 1^st class, just out of high school when he reported for duty on the deck of the Franklin, three months before the attack. Looking back on that day 68 years later, he said he was certain he was going to go down with the ship that morning, and ?that was the end.?

?But we were there for a purpose,? and despite suffering such heavy losses, Schauer says he still considers their mission ? keeping the ship afloat ? accomplished.

At the reunion on Friday, Medal of Honor recipient and retired Gen. James Livingston saluted the assembled veterans. He said their ?refusal to allow her to sink? allowed the Franklin to limp back to port instead of ending up buried forever on the ocean floor. ?That?s a testimony to what you are as men,? he said.

Terry Pickard / NBC News

The tattered battle flag from the USS Franklin hangs on display at the USS Yorktown.

In the belly of the USS Yorktown, another decommissioned carrier that saw battle in the Pacific and now survives as the centerpiece of the Patriots Point Naval Museum in this bucolic Charleston suburb, a tattered and smoke-tinged flag is mounted overhead. It was the original battle flag that flew on the mast of the Franklin?s flight deck the day of the attack -- the same flag that Rhodes remembers looking up and noticing through the haze of black smoke after the bombs hit. Seeing it meant they still had a chance, he remembered, ?because we would strike the colors before abandoning ship.? ??

?Big Ben? made it all the way back to New York for repairs, where it sat on V-J Day when the war finally ended. It never saw action again, and was sold for scrap in the 1960s. The flag, along with the bell and a gun turret also on display at the Yorktown, are all that remain of one of the most momentous spectacles of heroism and fortitude of World War II. And with what could be the final gathering of the men who saved the ship, it is up to a new generation to remember the Franklin.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2c12bec2/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A50C170C183253590Ewe0Esaved0Ethe0Eship0Ewwii0Evets0Efrom0Estricken0Eaircraft0Ecarrier0Egather0Elikely0Efor0Elast0Etime0Dlite/story01.htm

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Engadget Giveaway: win one of two CASIS patches, signed by Shepard Fairey!

Remember CASIS, the folks in charge of granting the public access to the national lab onboard the International Space Station, who were looking for the next great research project to send into space? Well, CASIS is still in the process of choosing the most deserving from among our reader submissions, but in the meantime, it's looking to give away a pair of the mission patches -- signed by their creator, famed designer Shepard Fairey -- from the inaugural orbital experiment scheduled to arrive on the ISS this fall. To enter for a chance to win one of these exclusive bits of space history, you need only venture beyond the break to read the rules of engagement and fill out the entry form. Best of luck folks, may the force of Fairey be with you.

Filed under: Announcements, HD, Mobile, Alt

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/n2SQC-duOBk/

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Two blasts at Iraqi Sunni mosque kill 43

BAQUBA, Iraq (Reuters) - Two bombs exploded outside a Sunni Muslim mosque in the Iraqi city of Baquba as worshippers left Friday prayers, killing at least 43 people in one of the deadliest attacks in a month-long surge in sectarian violence.

Several other bombings claimed lives around the country - with 19 killed near a commercial complex in the west of Baghdad, as mounting violence intensified fears of a return to all-out civil conflict.

Attacks on Sunni and Shi'ite mosques, security forces and tribal leaders have mounted since troops raided a Sunni protest camp near Kirkuk a month ago.

The increasingly sectarian civil war in neighboring Syria is emboldening Iraqi Sunni insurgents and straining relations between the two Muslim groups in Iraq, where tensions are at their worst since U.S. troops pulled out at the end of 2011.

On Friday, one bomb exploded outside the mosque in Baquba, about 50 km (30 miles) northeast of Baghdad, and a second explosion tore into crowds of people rushing to help victims of the first attack, police said.

Local television showed images of bodies, pools of blood and the victims' scattered shoes.

"I was about 30 meters from the first explosion. When the first exploded, I ran to help them, and the second one went off. I saw bodies flying and I had shrapnel in my neck," said Hashim Munjiz, a college student.

In the Amiriya district of western Baghdad, 19 people were killed by a roadside bomb, police and hospital sources said. Eight others died and more than 20 were wounded by a similar device targeting people gathering for the funeral of a Sunni Muslim cleric who was killed a day earlier.

COFFEE SHOP

Two more were killed in the southern outskirts of Baghdad at another funeral for someone who died in one of a series of attacks in the capital on Thursday.

Four others were killed when a roadside bomb exploded next to a coffee shop in the city of Falluja. A roadside bomb in the Doura district of southern Baghdad killed three, according to police and medics.

No group claimed responsibility for the attacks.

Shi'ite Islamist militias, which fought U.S. troops for years after the 2003 invasion, have said they are prepared in case they need to return to war. Sunni insurgents also sometimes hit Sunni targets to provoke conflict.

Sunni Islamist insurgents and al Qaeda's local wing, Islamic State of Iraq, have stepped up attacks since the start of the year to try to provoke a wide-scale sectarian confrontation like that which killed tens of thousands of Iraqis in 2006-2007.

The Sunni militants accuse Prime Minister Nuri al-Maliki's Shi'ite-led government of discriminating against their sect.

The United Nations said leaders from all groups needed to end the violence. "Small children are burned alive in cars. Worshippers are cut down outside their own mosques. This is beyond unacceptable," said U.N. envoy Martin Kobler.

April was Iraq's bloodiest month for almost five years, with 712 people killed, according to U.N. figures.

Since the U.S. withdrawal, Iraq's coalition government has been caught up in a power struggle between majority Shi'ites, minority Sunnis and ethnic Kurds who split cabinet posts between them.

Sunnis, who lost their dominance when the U.S.-led invasion toppled Saddam Hussein, have been protesting for months against Maliki, demanding reforms to tough anti-terrorism laws they say are used to unfairly target their sect.

Iraqi Sunni insurgents, some linked to al Qaeda, say they have formed an alliance with the al-Nusra Front Islamist group fighting against Syrian President Bashar al-Assad.

(Reporting by Kareem Raheem and Raheem Salman in Baghdad and a Reuters reporter in Baquba; Writing by Patrick Markey; Editing by Andrew Heavens and Robin Pomeroy)

Source: http://news.yahoo.com/least-eight-killed-blast-outside-sunni-mosque-iraqs-115003210.html

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Google wants Microsoft to remove the YouTube app in Windows Phone 8 because it doesn't show any ads.

Google wants Microsoft to remove the YouTube app in Windows Phone 8 because it doesn't show any ads. Understandable! But Microsoft says it would be happy to include advertising in the YouTube app... if Google gave Microsoft the proper APIs. Round and around we go. [Verge]

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/4Y-orKPauLw/google-wants-microsoft-to-remove-the-youtube-app-in-win-507020140

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